In late 2005, a video game based on the series entitled 'Game ni Natta yo! Dokuro-chan: Kenkō Shindan Daisakusen (ゲームになったよ!ドクロちゃん〜健康診断大作戦〜, lit. It's a Game Now! Dokuro-chan ~ Great Health Diagnosis Strategy) was released in Japan. The game was given a 18+ rating from CERO, because of highly disturbing violence and nudity. The game was re-rated as "D" (17+) on their website since this game was released while the "D" rating was not created. In the game, Sakura meets a new angel named Benomu. The game is set up as a visual novel where the player has to pick which opinions to go with. This game features the affection system, where the main character Sakura has to spend time with one of the six girls to maximize their heart meter and get the good ending for that character. Even though this game features voices, the minor characters still remains un-voiced, which results in only viewing text written on the screen while the character is silent. "Zansu" is one example. The voiced characters only include: Sakura, Zakuro, Dokuro, Benomu, Sabato and Shizuki.

There are videos in the game, but are recycled from the TV anime. The extremely violent scenes are censored by only showing a white screen with blood splatting all over it. However, the CG is all new and the game has over 90+ pictures. There are five mini-games added together in the game. Once the games are completed, the players gets a CG from the character of the player's choice. A challenge mode in the mini-game section is opened afterwards, where the player has to score 100 points on those five games to be able to make available a last chapter where Sakura dreams where all girls turn twelve-years-old; this chapter includes the remaining CGs of the characters.